HCID 19744814, 화합물 → 3-(1H-Imidazol-1-yl)benzenemethanol

HRID 2254450노트

반응식

HRID 2254450 반응식
C([O:3][C:4]([C:6]1[CH:7]=[C:8]([N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)[CH:9]=[CH:10][CH:11]=1)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-].C(Cl)(Cl)Cl.CO>C(OCC)C>[OH:3][CH2:4][C:6]1[CH:7]=[C:8]([N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)[CH:9]=[CH:10][CH:11]=1

참가 물질

5

반응물 3

HCID 19744814HCID 19744814, 화합물HCID 21226445Aluminium lithium hydrideHCID 21584188Chloroform methanol

생성물 1

HCID 197444983-(1H-Imidazol-1-yl)benzenemethanol수율 92%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

230 mg of 1-(3-ethoxycarbonylphenyl)imidazole see J. Am. Chem. Soc., 79, 4922 (1957)1 was dissolved in ml of ethyl ether, and 50 mg of lithium aluminium hydride was added. The mixture was stirred at room temperature for 2 hours. The reaction mixture was poured into ice water. The organic layer was separated and dried over anhydrous magnesium sulfate. The desiccant was separated by filtration. The solvent was evaporated and then the residue was purified by silica gel column chromatography Wakogel C-200, 20 g; eluting solvent: chloroform/methanol=20/1) to give 160 mg (yield 92%) of the captioned compound as a colorless oil.

후처리

  1. additionwas added
  2. customThe organic layer was separated
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe desiccant was separated by filtration
  5. customThe solvent was evaporated
  6. customthe residue was purified by silica gel column chromatography Wakogel C-200, 20 g

출처 및 근거

ORD 기록
ord-81e2dad3bd784cb0b040798920470948
출처 데이터셋
uspto-grants-1993_08
특허 번호
US05234946

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