Potassium Carbonate → 3-[3-(5-Oxazolyl)phenylthiomethyl)benzyl alcohol

반응식

[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:16]=[CH:17][CH:18]=1)[CH2:6][S:7][C:8]1[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=1)[CH:11]=[O:12].C1(C)C=CC(S([CH2:28][N+:29]#[C-:30])(=O)=O)=CC=1.C(=O)([O-])[O-].[K+].[K+]>>[O:12]1[C:11]([C:10]2[CH:9]=[C:8]([S:7][CH2:6][C:5]3[CH:4]=[C:3]([CH:18]=[CH:17][CH:16]=3)[CH2:2][OH:1])[CH:15]=[CH:14][CH:13]=2)=[CH:30][N:29]=[CH:28]1

참가 물질

반응물 3

HCID 11430Potassium Carbonate

HCID 161915Tosylmethyl isocyanide

HCID 197446443-[3-(Hydroxymethyl)benzylthio]benzaldehyde

생성물 1

HCID 678552663-[3-(5-Oxazolyl)phenylthiomethyl)benzyl alcohol수율 84.3%

실험 절차

When the same reaction as in Referential Example 33 was carried out except using 172 mg of the resulting aldehyde compound, 130 mg of p-toluenesulfonylmethyl isocyanide and 92 mg of potassium carbonate, 167 mg (yield 84%) of the captioned compound wss obtained.