Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Iodine → N-(4-iodo-3-methylphenyl)-N-methylmethanesulphonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Iodine | HCID 807 | — |
| 반응물 | Iodic acid | HCID 24345 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | N-Methyl-N-(3-tolyl)methanesulphonamide | HCID 19785598 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Sulfuric Acid | HCID 1118 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | N-(4-iodo-3-methylphenyl)-N-methylmethanesulphonamide | HCID 19785617 | 340% |
반응 단계
A solution of N-methyl-N-(3-tolyl)methanesulphonamide (0.12 g), iodine (76 g) and iodic acid (35 mg) in glacial acetic acid (5 ml) and concentrated sulphuric acid (0.6 ml) was stirred at 80° C. for 2.5 hours. Ethyl acetate (40 ml) and water (40 ml) were then added and the mixture neutralised with solid sodium bicarbonate. The organic phase was washed with brine (30 ml), dried (MgSO4) and the solvent evaporated to leave N-(4-iodo-3-methylphenyl)-N-methylmethanesulphonamide (0.22 g, 90%), m.p. 85°-87° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05236948 |
| 출처 데이터셋 | uspto-grants-1993_08 |
| ORD ID | ord-2ef0909f59a044baa0c31e4730d78f1d |
| 출처 메모 | uspto-grants-1993_08 |