5-(p-Cyanophenyl)imidazo[1,5-a]pyridine hydrochloride → Fadrozole

HRID 22547

반응식

HRID 22547 반응식
Cl.[C:2]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:15]3[CH:16]=[N:17][CH:18]=[C:14]3[CH:13]=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)#[N:3]>CO.[Pd]>[C:2]([C:4]1[CH:5]=[CH:6][C:7]([CH:10]2[N:15]3[CH:16]=[N:17][CH:18]=[C:14]3[CH2:13][CH2:12][CH2:11]2)=[CH:8][CH:9]=1)#[N:3]

참가 물질

4

반응물 1

HCID 199304145-(p-Cyanophenyl)imidazo[1,5-a]pyridine hydrochloride

생성물 1

HCID 59693Fadrozole

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of 54 mg of 5-(p-cyanophenyl)imidazo[1,5-a]pyridine hydrochloride in 5.0 ml methanol is hydrogenated at room temperature and atmospheric pressure for 30 min with 0.1 g of 10% palladium on charcoal. The catalyst is filtered and 0.21 ml of 1N sodium hydroxide is added. The filtrate is evaporated, taken up in 10 ml of methylene chloride and filtered through Celite®. Evaporation yields an oil which is chromatographed on silica gel with ethyl acetate to yield the title compound, m.p. 117°-118°.

후처리

  1. customis hydrogenated at room temperature
  2. filtrationThe catalyst is filtered
  3. addition0.21 ml of 1N sodium hydroxide is added
  4. customThe filtrate is evaporated
  5. filtrationfiltered through Celite®
  6. customEvaporation
  7. customyields an oil which
  8. customis chromatographed on silica gel with ethyl acetate

출처 및 근거

ORD 기록
ord-8a23494cdaa649afb524d0557bf17ef6
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05428160

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