Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → Fadrozole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | 5-(p-Bromophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine | HCID 14097196 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Fadrozole | HCID 59693 | — |
반응 단계
A mixture of 85 mg of 5-(p-bromophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine and 74 mg of cuprous cyanide in 1 ml of N,N-dimethylformamide is heated under nitrogen at 120° for 11 h. The reaction mixture is cooled, diluted with 10 ml of water and extracted with ethyl acetate. The organic extracts are dried over sodium sulfate and evaporated. The resulting oil is chromatographed on silica gel with ethyl acetate to yield the title compound, m.p. 117°-118°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05428160 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-00f7638125924cf68d1eb79ce35a532a |
| 출처 메모 | uspto-grants-1995_06 |