Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sulfuric Acid → Fadrozole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | Hydrazoic acid | HCID 24530 | — |
| 반응물 | 5-(p-Formylphenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine | HCID 14097198 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | Fadrozole | HCID 59693 | — |
반응 단계
A solution of 2.01 g of 5-(p-formylphenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine and 0.96 g of hydrazoic acid in 30 ml benzene is maintained by external cooling at room temperature, while 0.8 ml of concentrated sulfuric acid is added dropwise. The reaction mixture is stirred for 2 h and neutralized. The organic phase is separated, dried over sodium sulfate and evaporated to yield an oil which is chromatographed on silica gel with ethyl acetate to yield the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05428160 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-a545b507d80343d3b599544805a9709c |
| 출처 메모 | uspto-grants-1995_06 |