1,1-Dimethylethyl N-[2-[(4-chlorobenzoyl)amino]ethyl]carbamate → N-(2-Aminoethyl)-4-chlorobenzamide hydrochloride
반응식
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([C:6]([NH:8][CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)=[O:7])=[CH:4][CH:3]=1>C(O)=O>[ClH:1].[NH2:11][CH2:10][CH2:9][NH:8][C:6](=[O:7])[C:5]1[CH:19]=[CH:20][C:2]([Cl:1])=[CH:3][CH:4]=1참가 물질
3
실험 절차
A solution of 2.8 g of t-butyl [2-(4-chlorobenzamido)ethyl]carbamate in 50 ml of formic acid is left to stand at room temperature for 1.5 hours. The mixture is then concentrated to dryness, and the residue is dissolved in 50 ml of hydrochloric acid(l:l; volume/volume). The solution is concentrated, the residue is evaporated twice with ethanol/benzene and then recrystallized from ethanol. There are obtained 2.1 g of N-(2-aminoethyl)-4-chlorobenzamide hydrochloride which is identical with the product obtained in Example 1.
후처리
- concentration