Butylamine → N-n-butyl-3-methyl-5-isothiazolecarboxylic acid amide

HRID 2255487노트

반응식

HRID 2255487 반응식
[CH3:1][C:2]1[CH:6]=[C:5]([C:7]([OH:9])=O)[S:4][N:3]=1.C(N(CC)CC)C.[CH2:17]([NH2:21])[CH2:18][CH2:19][CH3:20]>C(OCC)(=O)C>[CH2:17]([NH:21][C:7]([C:5]1[S:4][N:3]=[C:2]([CH3:1])[CH:6]=1)=[O:9])[CH2:18][CH2:19][CH3:20]

참가 물질

5

반응물 3

HCID 8007ButylamineHCID 8471TriethylamineHCID 2740923-Methyl-1,2-thiazole-5-carboxylic acid

생성물 1

HCID 54219434N-n-butyl-3-methyl-5-isothiazolecarboxylic acid amide

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

3-Methyl-5-isothiazolecarboxylic acid (2.3 g) was dissolved in 40 ml of ethyl acetate. After 2 g of triethylamine were added, the resultant mixture was cooled over an ice-water bath and, at 5°-10° C., 1.5 g of n-butylamine were gradually added dropwise. After completion of the dropwise addition, stirring was continued for 30 minutes. The reaction mixture was washed successively with an aqueous solution of sodium hydrogencarbonate and then with water. After dried over sodium sulfate, the solvent was distilled off so that 2.60 g of N-n-butyl-3-methyl-5-isothiazolecarboxylic acid amide were obtained as an oil.

후처리

  1. additionAfter completion of the dropwise addition
  2. washThe reaction mixture was washed successively with an aqueous solution of sodium hydrogencarbonate
  3. dry with materialAfter dried over sodium sulfate
  4. distillationthe solvent was distilled off so that 2.60 g of N-n-butyl-3-methyl-5-isothiazolecarboxylic acid amide
  5. customwere obtained as an oil

출처 및 근거

ORD 기록
ord-d47183f2e5b3454a9a311f81fb228e31
출처 데이터셋
uspto-grants-1993_08
특허 번호
US05240951

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