Sulfuric Acid → 3,4-Dichloro-5-isothiazolecarboxylic acid amide

HRID 2255489노트

반응식

HRID 2255489 반응식
[C:1]([C:3]1[S:7][N:6]=[C:5]([Cl:8])[C:4]=1[Cl:9])#[N:2].S1C=CC=N1.S(=O)(=O)(O)[OH:16]>>[Cl:8][C:5]1[C:4]([Cl:9])=[C:3]([C:1]([NH2:2])=[O:16])[S:7][N:6]=1

참가 물질

4

반응물 3

HCID 1118Sulfuric AcidHCID 67515IsothiazoleHCID 19738264Dichloro-1,2-thiazole-5-carbonitrile

생성물 1

HCID 113330673,4-Dichloro-5-isothiazolecarboxylic acid amide

반응 조건

온도
110 °C

실험 절차

Concentrated sulfuric acid (10 ml) was added to 1.0 g of 5-cyano-3,4-dichloroisothiazole. When heated at 110° C. for 20 minutes, the isothiazole compound was dissolved completely. The reaction mixture was cooled under ice cooling, and precipitated crystals were collected by filtration. The crystals were then recrystallized from a 1:1 mixed solvent of ethanol and water.

후처리

  1. temperatureThe reaction mixture was cooled under ice cooling
  2. customprecipitated crystals
  3. filtrationwere collected by filtration
  4. customThe crystals were then recrystallized from a 1:1 mixed solvent of ethanol and water

출처 및 근거

ORD 기록
ord-d7ac6bbb142a47bb9ad3c6bbee0a4550
출처 데이터셋
uspto-grants-1993_08
특허 번호
US05240951

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