Isopropylamine → Isopropylammonium 3-methyl-5-isothiazolecarboxylate

HRID 2255490노트

반응식

HRID 2255490 반응식
[CH3:1][C:2]1[CH:6]=[C:5]([C:7]([OH:9])=[O:8])[S:4][N:3]=1.[CH:10]([NH2:13])([CH3:12])[CH3:11]>O1CCCC1>[CH3:1][C:2]1[CH:6]=[C:5]([C:7]([O-:9])=[O:8])[S:4][N:3]=1.[CH:10]([NH3+:13])([CH3:12])[CH3:11]

참가 물질

4

반응물 2

HCID 6363IsopropylamineHCID 2740923-Methyl-1,2-thiazole-5-carboxylic acid

생성물 1

HCID 19738253Isopropylammonium 3-methyl-5-isothiazolecarboxylate수율 85.5%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

3-Methyl-5-isothiazolecarboxylic acid (1.0 g) was dissolved in 10 ml of dry tetrahydrofuran, in which a solution of 0.41 g of isopropylamine in 5 ml of dry tetrahydrofuran were added dropwise at room temperature under stirring. White crystals were formed concurrently with the dropwise addition. After the reaction mixture was stirred further at room temperature for 30 minutes, crystals were collected by filtration and washed with a small amount of dry tetrahydrofuran. The crystals were dried at 40° C. for 3 hours under reduced pressure, whereby 1.20 g of the title compound were obtained (yield: 85%).

후처리

  1. additionwere added dropwise at room temperature
  2. customWhite crystals were formed concurrently with the dropwise addition
  3. stirringAfter the reaction mixture was stirred further at room temperature for 30 minutes
  4. filtrationcrystals were collected by filtration
  5. washwashed with a small amount of dry tetrahydrofuran
  6. customThe crystals were dried at 40° C. for 3 hours under reduced pressure

출처 및 근거

ORD 기록
ord-f0a0db6f45a5443492cc50a77ba0e767
출처 데이터셋
uspto-grants-1993_08
특허 번호
US05240951

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