Butanoic acid, 3-(acetyloxy)-2-methylene-, ethyl ester → ethyl 2-[(1R)-1-hydroxyethyl]acrylate

HRID 2255658노트

반응식

HRID 2255658 반응식
C([O:4][CH:5]([C:7](=[CH2:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH3:6])(=O)C>P([O-])([O-])([O-])=O>[OH:4][C@@H:5]([C:7](=[CH2:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH3:6]

참가 물질

3

반응물 1

HCID 11063122Butanoic acid, 3-(acetyloxy)-2-methylene-, ethyl ester

생성물 1

HCID 10975602ethyl 2-[(1R)-1-hydroxyethyl]acrylate수율 38.5%

시약·촉매·용매 1

HCID 1061Phosphate용매

실험 절차

A mixture of ethyl 2-(1-acetoxyethyl)acrylate (1 g) and Lipase (0.25 g) in 0.1M phosphate buffer solution (pH 7.0) (80 ml) was stirred at room temperature for 60 hours. The whole mixture was extracted three times with ethyl acetate and the combined extracts were dried over magnesium sulfate. After removal of the solvent in vacuo, the crude product was purified by column chromatography on silica gel (eluent : a mixture of hexane and ethyl acetate, 2:1) to give ethyl 2-[(1R)-1-hydroxyethyl]acrylate (298 mg).

후처리

  1. extractionThe whole mixture was extracted three times with ethyl acetate
  2. dry with materialthe combined extracts were dried over magnesium sulfate
  3. customAfter removal of the solvent in vacuo
  4. customthe crude product was purified by column chromatography on silica gel (eluent
  5. additiona mixture of hexane and ethyl acetate, 2:1)

출처 및 근거

ORD 기록
ord-dff8629690a9455aab14e563d877a906
출처 데이터셋
uspto-grants-1993_08
특허 번호
US05241064

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