Butanoic acid, 3-(acetyloxy)-2-methylene-, ethyl ester → ethyl 2-[(1R)-1-hydroxyethyl]acrylate

HRID 2255663노트

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HRID 2255663 반응식
C([O:4][CH:5]([C:7](=[CH2:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH3:6])(=O)C>P([O-])([O-])([O-])=O>[OH:4][C@@H:5]([C:7](=[CH2:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH3:6]

참가 물질

3

반응물 1

HCID 11063122Butanoic acid, 3-(acetyloxy)-2-methylene-, ethyl ester

생성물 1

HCID 10975602ethyl 2-[(1R)-1-hydroxyethyl]acrylate수율 41.3%

시약·촉매·용매 1

HCID 1061Phosphate용매

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온도
37 °C

실험 절차

A mixture of ethyl 2-(1-acetoxyethyl)acrylate (35.65 g) and "Lipase P" (8.88 g) in pH 7.0 phosphate buffer (0.1M) (2.8 l) was stirred at 37° C. for 72 hours. The whole mixture was extracted with ethyl acetate, and the combined extracts were dried. After removal at the solvent from the solution in vacuo, the crude product was purified by column-chromatography on silica gel (eluent : a mixture of hexane and ethyl acetate, 2:1) to give ethyl 2-[(1R)-1-hydroxyethyl]acrylate (11.40 g).

후처리

  1. extractionThe whole mixture was extracted with ethyl acetate
  2. customthe combined extracts were dried
  3. customAfter removal at the solvent from the solution in vacuo
  4. customthe crude product was purified by column-chromatography on silica gel (eluent
  5. additiona mixture of hexane and ethyl acetate, 2:1)

출처 및 근거

ORD 기록
ord-0cd7294c2f2d4b569dee246edd633c4c
출처 데이터셋
uspto-grants-1993_08
특허 번호
US05241064

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