1-Benzyloxycarbonyl-4-(3-pyridyl)-1,2,3,4-tetrahydropyridine → 3-(Piperidin-4-yl)pyridine
반응식
C(OC([N:11]1[CH:16]=[CH:15][CH:14]([C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)[CH2:13][CH2:12]1)=O)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[N:19]1[CH:20]=[CH:21][CH:22]=[C:17]([CH:14]2[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]2)[CH:18]=1참가 물질
5
실험 절차
A solution of 1-benzyloxycarbonyl-4-(3-pyridyl)-1,2,3,4-tetrahydropyridine (0.714 in ethanol (50 mL) was treated with 10% palladium on carbon (0.1 g) and hydrogenated under a hydrogen atmosphere at room temperature and 3.44 bar for 16 hours. The reaction mixture was filtered through diatomaceous earth to remove the catalyst, and the resulting filtrate was evaporated to afford the piperidine (0.393 g); NMR (CDCl3): 1.7 (m, 4), 2.8 (m, 4), 3.2 (m, 2), 7.3 (m, 1), 7.5 (m, 1), 8.5 (m, 2); MS: m/z=162(M+1).
후처리
- filtrationThe reaction mixture was filtered through diatomaceous earth
- customto remove the catalyst
- customthe resulting filtrate was evaporated
출처 및 근거
- ORD 기록
- ord-64a60d14893e4aad8b0b7d8105db3be9
- 출처 데이터셋
- uspto-grants-1997_08
- 특허 번호
- US05654299
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