6-Benzyl-5,7-dihydro-5,7-dioxopyrrolo[3,4-b]pyridine → Tetrahydro-6-(phenylmethyl)-1H-pyrrolo(3,4-b)pyridine-5,7(2H,6H)-dione

HRID 2256080

반응식

HRID 2256080 반응식
[CH2:1]([N:8]1[C:16](=[O:17])[C:15]2[C:10](=[N:11][CH:12]=[CH:13][CH:14]=2)[C:9]1=[O:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Ru].COCCO>[CH2:1]([N:8]1[C:16](=[O:17])[CH:15]2[CH:10]([NH:11][CH2:12][CH2:13][CH2:14]2)[C:9]1=[O:18])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 2895026-Benzyl-5,7-dihydro-5,7-dioxopyrrolo[3,4-b]pyridine

생성물 1

HCID 9899604Tetrahydro-6-(phenylmethyl)-1H-pyrrolo(3,4-b)pyridine-5,7(2H,6H)-dione수율 101.4%

시약·촉매·용매 2

HCID 23950Ruthenium촉매HCID 80192-Methoxyethanol용매

실험 절차

To 10 g of 6-benzyl-5,7-dihydro-5,7-dioxopyrrolo[3.4-b]pyridine were added 84 ml of 2-methoxyethanol and 1.5 g of a ruthenium-on-carbon catalyst, and hydrogenation was conducted under a pressurized hydrogen gas atmosphere at 4.5 kg/cm2 for 22 hours. The catalyst was removed by filtration, and the filtrate was concentrated. To the concentrate were added 84 ml of 2-methoxyethanol and 2 g of a palladium-on-charcoal catalyst, and hydrogenation was conducted under a pressurized hydrogen gas atmosphere at 4.5 kg/cm2 for 7 hours. The catalyst was removed by filtration, and the filtrate was concentrated to yield 10.4 g of the titled compound. Throughout the hydrogenation, the reaction vessel was heated by a tungsten lamp.

후처리

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated
  3. additionTo the concentrate were added 84 ml of 2-methoxyethanol and 2 g of a palladium-on-charcoal catalyst, and hydrogenation
  4. waitwas conducted under a pressurized hydrogen gas atmosphere at 4.5 kg/cm2 for 7 hours
  5. customThe catalyst was removed by filtration
  6. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-52e932c815334e81861cd2b7329b7102
출처 데이터셋
uspto-grants-1997_08
특허 번호
US05654318

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