Acetyl chloride → 4-(1,3-Dioxaindan-5-yl)oxane-2,6-dione

반응식

[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]([CH2:15][C:16]([OH:18])=[O:17])[CH2:11][C:12]([OH:14])=O)=[CH:9][C:4]=2[O:3][CH2:2]1.C(Cl)(=O)C>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]3[CH2:11][C:12](=[O:14])[O:18][C:16](=[O:17])[CH2:15]3)=[CH:9][C:4]=2[O:3][CH2:2]1

참가 물질

반응물 2

HCID 6367Acetyl chloride

HCID 332828HCID 332828, 화합물

생성물 1

HCID 219278554-(1,3-Dioxaindan-5-yl)oxane-2,6-dione수율 97.9%

실험 절차

3-(1,3-benzodioxol-5-yl)glutaric acid (3.2 g) was treated with acetyl chloride (15 mL) and the resulting mixture heated at reflux for 5 hours. The cooled reaction mixture was then azeotroped with toluene (2×100 mL) and concentrated under reduced pressure. The residue was slurried with diethyl ether and filtered to afford the title compound (2.91 g).

후처리

temperaturethe resulting mixture heated
temperatureat reflux for 5 hours
customThe cooled reaction mixture
customwas then azeotroped with toluene (2×100 mL)
concentrationconcentrated under reduced pressure
filtrationfiltered

출처 및 근거

ORD 기록: ord-8e4d43cfa15241d7b249ba2e450e223c
출처 데이터셋: uspto-grants-1997_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05654316

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