3-Oxa-8-azabicyclo(3.2.1)octane hydrochloride → HCID 57753727, 화합물

HRID 225665

반응식

HRID 225665 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12](I)=[C:13]([Cl:17])[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.[CH:20]12[NH:27][CH:24]([CH2:25][CH2:26]1)[CH2:23][O:22][CH2:21]2>>[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([N:27]3[CH:20]4[CH2:26][CH2:25][CH:24]3[CH2:23][O:22][CH2:21]4)=[C:13]([Cl:17])[CH:14]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 534011293-Oxa-8-azabicyclo(3.2.1)octane hydrochlorideHCID 577534555-Chloro-6-iodo-1,3-dihydro-isoindole-2-carboxylic Acid Tert-Butyl Ester

생성물 1

HCID 57753727HCID 57753727, 화합물

실험 절차

Prepared in analogy to Example A3(d) from 5-chloro-6-iodo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (Example A3(c)) and 3-oxa-8-azabicyclo[3.2.1]octane hydrochloride. Yellow solid. MS (m/e): 367.1 ([{37Cl}M+H]+, 35%), 365.1 ([{35Cl}M+H]+, 100%).

출처 및 근거

ORD 기록
ord-6bcb253f43724da78b80445a9170d4d0
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07557114B2

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