Methylamine → 3-Benzyloxycarbonylamino-2(R,S)-methylpropionic acid N-methylamide

HRID 2256763노트

반응식

HRID 2256763 반응식
C[O:2][C:3](=O)[CH:4]([CH3:17])[CH2:5][NH:6][C:7]([O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:8].[CH3:19][NH2:20]>>[CH3:19][NH:20][C:3](=[O:2])[CH:4]([CH3:17])[CH2:5][NH:6][C:7]([O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:8]

참가 물질

3

반응물 2

HCID 6329MethylamineHCID 223644703-Benzyloxycarbonylamino-2(r,s)-methylpropionic acid methyl ester

생성물 1

HCID 223644733-Benzyloxycarbonylamino-2(R,S)-methylpropionic acid N-methylamide

실험 절차

2.52 g of 3-benzyloxycarbonylamino-2(R,S)-methylpropionic acid methyl ester and 50 ml of 33% methylamine (in ethanol) are stirred at room temperature for 48 hours. The reaction mixture is concentrated by evaporation and the title compound is obtained from the residue by crystallisation from ethyl acetate: Rf (dichloromethane/methanol=95:5)=0.42; m.p. 128°-129° C.

후처리

  1. concentrationThe reaction mixture is concentrated by evaporation

출처 및 근거

ORD 기록
ord-8f54522d0b104094b666bb29006c8d84
출처 데이터셋
uspto-grants-1997_08
특허 번호
US05654445

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