Methanol → HCID 19027583, 화합물

HRID 2256811노트

반응식

HRID 2256811 반응식
[C:1]1([C:7]2[N:11]=[C:10]([CH2:12][CH2:13][C:14](O)=[O:15])[O:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CO>O1CCCC1>[C:1]1([C:7]2[N:11]=[C:10]([CH2:12][CH2:13][CH2:14][OH:15])[O:9][N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 887MethanolHCID 6659683-(3-phenyl-1,2,4-oxadiazol-5-yl)propanoic acid

생성물 1

HCID 19027583HCID 19027583, 화합물수율 56.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of 2.5 ml of borane-methyl sulfide complex in 2M solution in tetrahydrofuran, 920 mg of 3-(3-phenyl-1,2,4-oxadiazol 5-yl)-propanoic acid (prepared by SRIRASTAVA et al., J. Heterocycl. Chem., Vol. 21, p. 1193 (1984) and 20 ml of tetrahydrofuran was stirred for one hour at ambient temperature. 10 ml of methanol were added over 5 minutes and evaporation to dryness under reduced pressure was carried out. The residue was chromatographed on silica (eluant: ethyl acetate - hexane (6-4)) to obtain 485 mg of the expected product.

후처리

  1. customevaporation to dryness under reduced pressure
  2. customThe residue was chromatographed on silica (eluant: ethyl acetate - hexane (6-4))

출처 및 근거

ORD 기록
ord-d6a7c392a358417da35aeb7f62c06421
출처 데이터셋
uspto-grants-1997_08
특허 번호
US05656607

반응 노트

불러오는 중…