Water → 2,3-Dichloro-4-trifluoromethoxybenzoic acid

HRID 2256918

반응식

HRID 2256918 반응식
[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([O:12][C:13]([F:16])([F:15])[F:14])[CH:8]=[CH:7][C:3]=1[C:4](F)=[O:5].[OH2:17]>>[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([O:12][C:13]([F:16])([F:15])[F:14])[CH:8]=[CH:7][C:3]=1[C:4]([OH:17])=[O:5]

참가 물질

3

반응물 2

HCID 962WaterHCID 539612062,3-Dichloro-4-trifluoromethoxybenzoyl fluoride

생성물 1

HCID 543779072,3-Dichloro-4-trifluoromethoxybenzoic acid

실험 절차

A suspension of crude 2,3-dichloro4-trifluoromethoxybenzoyl fluoride (2 g, containing mixed antimony halides) in water was stirred vigorously for 24 hours. The mixture was extracted with dichloromethane and filtered. The organic layer was washed with hydrochloric acid (2M), aqueous sodium chloride solution and extracted into sodium carbonate solution (2M). The aqueous extract was acidified to pH1 and the solid was filtered off and washed with water to give 2,3-dichloro-4-trifluoromethoxybenzoic acid (0.6 g) as a white solid mp 123°-126° C.

후처리

  1. extractionThe mixture was extracted with dichloromethane
  2. filtrationfiltered
  3. washThe organic layer was washed with hydrochloric acid (2M), aqueous sodium chloride solution
  4. extractionextracted into sodium carbonate solution (2M)
  5. extractionThe aqueous extract
  6. filtrationthe solid was filtered off
  7. washwashed with water

출처 및 근거

ORD 기록
ord-d3baf745aea248a3a776d22d9b203a3d
출처 데이터셋
uspto-grants-1997_08
특허 번호
US05656573

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