2,2,2-Trifluoroethanol → 5-Methanesulfonyl-2-(2,2,2-trifluoro-ethoxy)-benzoic acid

HRID 225701노트

반응식

HRID 225701 반응식
Cl[C:2]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[F:15][C:16]([F:20])([F:19])[CH2:17][OH:18]>>[CH3:14][S:11]([C:8]1[CH:9]=[CH:10][C:2]([O:18][CH2:17][C:16]([F:20])([F:19])[F:15])=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5])(=[O:13])=[O:12]

참가 물질

3

반응물 2

HCID 64092,2,2-TrifluoroethanolHCID 23291322-Chloro-5-(methylsulphonyl)benzoic acid

생성물 1

HCID 211003125-Methanesulfonyl-2-(2,2,2-trifluoro-ethoxy)-benzoic acid

실험 절차

Prepared in analogy to Example B1(b) from 2-chloro-5-methanesulfonyl-benzoic acid (Example B1(a)) and 2,2,2-trifluoro-ethanol. The crude material was purified by preparative HPLC to yield the title compound as a white solid. MS (m/e): 297.0 ([M−H]−, 100%).

후처리

  1. customThe crude material was purified by preparative HPLC

출처 및 근거

ORD 기록
ord-8b4c86bfaa334562a3998643bfd9312b
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07557114B2

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