참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triphenylarsine | HCID 11773 | — |
| 반응물 | Tributylphenyltin | HCID 607632 | — |
| 반응물 | Methyl 2-iodo-5-(methylsulfonyl)benzoate | HCID 59853752 | — |
| 촉매 | Copper iodide | HCID 83717 | — |
| 촉매 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-Methanesulfonyl-biphenyl-2-carboxylic acid methyl ester | HCID 57753217 | 99% |
반응 단계
A mixture of 3.53 mmol 2-Iodo-5-methanesulfonyl-benzoic acid methyl ester, 3.88 mmol Phenyltri-n-butyltin, 0.25 mmol Tris(dibenzylideneacetone)dipalladium(0), 0.35 mmol Triphenylarsine and 1.62 mmol Copper iodide in N,N-Dimethylformamide (30 ml) was heated at 90° C. for 16 hours. The mixture was cooled to room temperature and concentrated in vacuo. The residue was chromatographed over SiO2 (ethyl acetate/heptane gradient) to provide the title compound (99%) as an off-white crystalline solid. MS (m/e): 291.0 (MH+, 100%)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07557114B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_07 |
|---|
| ORD ID | ord-080b43447f2e4e1ea5a6295673c01f4d |
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| 출처 메모 | uspto-grants-2009_07 |
|---|
