2-Aminothiazole → Thiourea, N-ethyl-N'-2-thiazolyl-
반응식
[CH2:1]([N:3]=[C:4]=[S:5])[CH3:2].[NH2:6][C:7]1[S:8][CH:9]=[CH:10][N:11]=1.C(OCC)(=O)C>CN(C)C=O>[CH2:1]([NH:3][C:4]([NH:6][C:7]1[S:8][CH:9]=[CH:10][N:11]=1)=[S:5])[CH3:2]참가 물질
5
실험 절차
A solution of ethyl isothiocyanate (1.74 g, 20 mmol) and 2-aminothiazole (2.0 g, 20 mmol) in N,N-dimethylformamide (50 mL) was heated at 100° C. for 23 h. The reaction was cooled to room temperature, poured into ethyl acetate, washed with water, 1N aqueous HCl, water, saturated sodium bicarbonate, and brine. The organic layer was concentrated and the residue recrystallized twice from ethyl acetate to provide 0.48 g (13%) of the title product:
후처리
- washwashed with water, 1N aqueous HCl, water, saturated sodium bicarbonate, and brine
- concentrationThe organic layer was concentrated
- customthe residue recrystallized twice from ethyl acetate
출처 및 근거
- ORD 기록
- ord-4fd4789e1ea449ba8f4f1e20a0781ce4
- 출처 데이터셋
- uspto-grants-1997_08
- 특허 번호
- US05658907
반응 노트
불러오는 중…