2,4-Dimethoxyphenyl isocyanate → Ethyl 2-(4-{2-[3-(2,4-dimethoxyphenyl)-1-heptylureido]ethyl}phenoxy)-2-methylpropionate

HRID 2258022노트

반응식

HRID 2258022 반응식
[CH2:1]([NH:8][CH2:9][CH2:10][C:11]1[CH:25]=[CH:24][C:14]([O:15][C:16]([CH3:23])([CH3:22])[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:13][CH:12]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[CH3:26][O:27][C:28]1[CH:33]=[C:32]([O:34][CH3:35])[CH:31]=[CH:30][C:29]=1[N:36]=[C:37]=[O:38]>C(Cl)Cl>[CH3:26][O:27][C:28]1[CH:33]=[C:32]([O:34][CH3:35])[CH:31]=[CH:30][C:29]=1[NH:36][C:37](=[O:38])[N:8]([CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][C:14]([O:15][C:16]([CH3:23])([CH3:22])[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:24][CH:25]=1)[CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

참가 물질

4

반응물 2

HCID 6016372,4-Dimethoxyphenyl isocyanateHCID 23192930Ethyl 2-[4-(heptylaminoethyl)phenoxy]-2-methylpropionate

생성물 1

HCID 22924175Ethyl 2-(4-{2-[3-(2,4-dimethoxyphenyl)-1-heptylureido]ethyl}phenoxy)-2-methylpropionate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The product from step (d) (2.1 g) and 2,4-dimethoxyphenylisocyanate (1.1 g, Aldrich) were dissolved in CH2Cl2 (50 ml). The resulting solution was stirred at room temperature for 17 hours and then evaporated in vacuo. The residue was flash chromatographed through a silica column using hexanes/CH2C1 /EtOAc (50:25:25) as eluant to give the desired product as a very light brown oil (2.0 g).

후처리

  1. customevaporated in vacuo
  2. customchromatographed through a silica column

출처 및 근거

ORD 기록
ord-c033c022daa94816a823a761b469f875
출처 데이터셋
uspto-grants-1997_08
특허 번호
US05658944

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