홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Potassium Hydroxide → (E)-N-Methyl-2-[3-(4-hydroxy-1-methyl-4-piperidinyl)-1H-indol-5-yl]ethenesulphonamide

HRID 2258134
노트
인쇄 미리보기

반응식

HRID 2258134 반응식
[CH3:1][NH:2][S:3](/[CH:6]=[CH:7]/[C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[NH:13][CH:12]=[CH:11]2)(=[O:5])=[O:4].[CH3:17][N:18]1[CH2:23][CH2:22][C:21](=[O:24])[CH2:20][CH2:19]1.[OH-].[K+]>CCOCC>[CH3:1][NH:2][S:3](/[CH:6]=[CH:7]/[C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[NH:13][CH:12]=[C:11]2[C:21]1([OH:24])[CH2:22][CH2:23][N:18]([CH3:17])[CH2:19][CH2:20]1)(=[O:5])=[O:4]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 14797Potassium HydroxideHCID 740491-Methyl-4-piperidoneHCID 134757642-(1H-indol-5-yl)-N-methylethenesulfonamide

생성물 1

HCID 19068423(E)-N-Methyl-2-[3-(4-hydroxy-1-methyl-4-piperidinyl)-1H-indol-5-yl]ethenesulphonamide수율 64%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A mixture of (E)-N-methyl-2-(1H-indole-5-yl)ethenesulphonamide (2.0 g), 1-methyl-4-piperidone (1.62 g) and potassium hydroxide (0.7 g) in IMS (20 mL) was stirred at ambient temperature for 22 hr. The reaction mixture was concentrated and the residue purified by column chromatography on silica gel. Eluting with dichloromethane/ethanol/ammonia (25:10:1) gave an oil which solidified on standing to a brown solid. Trituration with ether provided the product as a white powder (1.85 g, 64% of theory).

후처리

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue purified by column chromatography on silica gel
  3. washEluting with dichloromethane/ethanol/ammonia (25:10:1)
  4. customgave an oil which

출처 및 근거

ORD 기록
ord-a98f55042771491cb8e73dff09c3e775
출처 데이터셋
uspto-grants-1997_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05659040

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트