Pentane, 1-bromo-5-fluoro- → HCID 178506028, 화합물

HRID 2258175

반응식

HRID 2258175 반응식
[F:1][CH2:2][CH2:3][CH2:4][CH2:5]CBr.[Mg].Cl[SiH:10]1[CH2:15][CH2:14][CH:13]([C:16]2[CH:21]=[CH:20][C:19]([C:22]3[CH:27]=[CH:26][C:25]([F:28])=[C:24]([F:29])[CH:23]=3)=[CH:18][CH:17]=2)[CH2:12][CH2:11]1>C1COCC1>[F:1][CH2:2][CH2:3][CH2:4][CH2:5][Si@H:10]1[CH2:15][CH2:14][C@H:13]([C:16]2[CH:21]=[CH:20][C:19]([C:22]3[CH:27]=[CH:26][C:25]([F:28])=[C:24]([F:29])[CH:23]=3)=[CH:18][CH:17]=2)[CH2:12][CH2:11]1

참가 물질

5

반응물 3

HCID 120236Pentane, 1-bromo-5-fluoro-HCID 5462224MagnesiumHCID 1317201274'-(4-Chloro-4-silacyclohexyl)-3,4-difluorobiphenyl

생성물 1

HCID 178506028HCID 178506028, 화합물수율 74%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

3.4 g (20 mmol) of fluoropentyl bromide was dripped into a mixture of 0.5 g of magnesium (21 mmol) and 50 ml of THF to obtain a Grignard's reagent. This solution was then dripped into a 50 ml THF solution of 6.5 g (20 mmol) of 4'-(4-chloro-4-silacyclohexyl)-3,4-difluorobiphenyl to obtain 4'-(trans-4-(4-fluorobutyl)-4-silacyclohexyl)-3,4-difluorobiphenyl. The silacyclohexane rings of this product were a mixture of trans isomers and cis isomers. They were separated by means of chromatography to obtain 6.3 g of the trans isomers (yield 74%).

후처리

  1. customto obtain a Grignard's reagent

출처 및 근거

ORD 기록
ord-88dc1604f7954f13a941462e1f82e0b7
출처 데이터셋
uspto-grants-1997_08
특허 번호
US05659059

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