Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,4,7,10-Tetraazacyclododecane → alpha-Ethyl-2,4,6-triiodo-3-[[1-oxo-6-[(1,4,7,10-tetraazacyclododec-1-yl-acetyl)amino]hexyl]amino]benzenepropanoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,4,7,10-Tetraazacyclododecane | HCID 64963 | — |
| 반응물 | 3-[[6-[(Chloroacetyl)amino]-1-oxohexyl]amino]-alpha-ethyl-2,4,6-triiodobenzenepropanoic acid | HCID 22921401 | — |
| 용매 | Dimethylacetamide | HCID 31374 | — |
| 생성물 | alpha-Ethyl-2,4,6-triiodo-3-[[1-oxo-6-[(1,4,7,10-tetraazacyclododec-1-yl-acetyl)amino]hexyl]amino]benzenepropanoic acid | HCID 22921393 | 59% |
반응 단계
According to the procedure described in Example 5, 171.3 g of 1,4,7,10-tetraazacyclododecane (1,00 mol) in 500 ml of DMA are reacted with 190 g of 3-[[6-[(chloroacetyl) amino]-1-oxohexyl]amino]-α-ethyl-2,4,6-triiodobenzenepropanoic acid (prepared according to the procedure described in Example 2) (0,25 mol) in 250 ml of DMA. 155 g of α-ethyl-2,4,6-triiodo-3-[[1-oxo-6-[(1,4,7,10-tetraazacyclododec-1-yl-acetyl)amino]hexyl]amino]benzenepropanoic acid (0.147 mol) are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05660814 |
| 출처 데이터셋 | uspto-grants-1997_08 |
| ORD ID | ord-d3a29fcf993e497388fdefede7c9e7bc |
| 출처 메모 | uspto-grants-1997_08 |