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Diethyl Ether → Dimethyl 5-(3-((7-chloroquinolin-2-yl-methyl)oxy)phenyl)-4,6-dithianonanedioate

HRID 22585
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인쇄 미리보기

반응식

HRID 22585 반응식
Br[CH2:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][C:7]([Cl:13])=[CH:8][CH:9]=2)[N:4]=1.[OH:14][C:15]1[CH:16]=[C:17]([CH:21]([S:29][CH2:30][CH2:31][C:32]([O:34][CH3:35])=[O:33])[S:22][CH2:23][CH2:24][C:25]([O:27][CH3:28])=[O:26])[CH:18]=[CH:19][CH:20]=1.C([O-])([O-])=O.[K+].[K+].CCOCC>C(C(C)=O)C>[Cl:13][C:7]1[CH:6]=[C:5]2[C:10]([CH:11]=[CH:12][C:3]([CH2:2][O:14][C:15]3[CH:16]=[C:17]([CH:21]([S:22][CH2:23][CH2:24][C:25]([O:27][CH3:28])=[O:26])[S:29][CH2:30][CH2:31][C:32]([O:34][CH3:35])=[O:33])[CH:18]=[CH:19][CH:20]=3)=[N:4]2)=[CH:9][CH:8]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 3283Diethyl EtherHCID 11430Potassium CarbonateHCID 9997621Dimethyl 5-(3-hydroxyphenyl)-4,6-dithianonanedioateHCID 102441602-(Bromomethyl)-7-chloroquinoline

생성물 1

HCID 9984156Dimethyl 5-(3-((7-chloroquinolin-2-yl-methyl)oxy)phenyl)-4,6-dithianonanedioate

시약·촉매·용매 1

HCID 6569
Methyl Ethyl Ketone
용매

실험 절차

A mixture of 2-bromomethyl-7-chloroquinoline (2.5 g) (Step 2), phenol (Step 1) (3.4 g) and K2CO3 (3 g) was heated at reflux for 4 hours in methyl ethyl ketone (100 ml). The reaction mixture was cooled and ether (100 ml) was added. The suspension was filtered and evaporated. Flash chromatography of the residue using 30% ethyl acetate in hexane afforded the title compound.

후처리

  1. temperaturewas heated
  2. temperatureThe reaction mixture was cooled
  3. filtrationThe suspension was filtered
  4. customevaporated

출처 및 근거

ORD 기록
ord-86bc6ded7c5243dc8a634f420e63159d
출처 데이터셋
uspto-grants-1995_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05428171

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