Formic Acid → 6-Bromo-4H-imidazo[4,5-b]pyridine

HRID 225854

반응식

HRID 225854 반응식
[Br:1][C:2]1[CH:3]=[C:4]([NH2:9])[C:5]([NH2:8])=[N:6][CH:7]=1.[CH:10](O)=O>>[Br:1][C:2]1[CH:3]=[C:4]2[N:9]=[CH:10][NH:8][C:5]2=[N:6][CH:7]=1

참가 물질

3

반응물 2

HCID 284Formic AcidHCID 6911565-Bromopyridine-2,3-diamine

생성물 1

HCID 9115786-Bromo-4H-imidazo[4,5-b]pyridine

실험 절차

5-Bromo-2,3-diaminopyridine (1.69 g, 8.99 mmole) was taken up in 96% formic acid (50 mL) and heated to reflux. After 18 hr the mixture was cooled to RT and concentrated. The residue was taken up in H2O and the pH was adjusted to 7 with 2.0 M NaOH. The title compound (1.54 g, 87%) was collected as a solid by filtration, washed with H2O, and dried in vacuo: MS (ES) m/e 198/200 (M+H)+.

후처리

  1. temperatureheated to reflux
  2. concentrationconcentrated
  3. filtrationThe title compound (1.54 g, 87%) was collected as a solid by filtration
  4. washwashed with H2O
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-b165cda73e6748da8313f0426aca20ec
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07557125B2

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