Guanidine → 5,6-dihydro-3-(methylamino)benzo[f]quinazolin-1(2H)-one
반응식
O[C:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]=1[C:12]([O:14]C)=O.[CH3:16][NH:17][C:18]([NH2:20])=[NH:19].NC(N)=N>>[CH3:16][NH:17][C:18]1[NH:20][C:12](=[O:14])[C:3]2[C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][C:9]=3[CH2:10][CH2:11][C:2]=2[N:19]=1참가 물질
4
실험 절차
Methyl 3,4-dihydro-2-hydroxy-1-naphthoate was reacted with methylguanidine in the same manner as for the analogous reaction using guanidine (example 1) to obtain 5,6-dihydro-3-(methylamino)benzo[f]quinazolin-1(2H)-one. 1H NMR(DMSO-d6, 200 MHz) δ: 2.52-2.64(m, 2H, CH2), 2.68-2.82(m, 2H, CH2), 2.81(d, J=5 Hz, 3H, NCH3), 6.54(br s, 1H, C3NH), 7.02 (ddd, J=8, 8, 2 Hz, 1H, Ar), 7.07-7.18(m, 2H, Ar), 8.42(dd, J=8,2 Hz, 1H, Ar), 10.98(br s, 1H, N2H).
출처 및 근거
- ORD 기록
- ord-bcbe30765d874c4ca625cb017a7214e2
- 출처 데이터셋
- uspto-grants-1997_08
- 특허 번호
- US05661155
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