Trifluoroacetic acid → 2-Bromo-1-methyl-1H-pyrrole-3-sulfonamide

HRID 2259183

반응식

HRID 2259183 반응식
[Br:1][C:2]1[N:3]([CH3:15])[CH:4]=[CH:5][C:6]=1[S:7]([NH:10]C(C)(C)C)(=[O:9])=[O:8].C(O)(C(F)(F)F)=O>C(Cl)Cl>[Br:1][C:2]1[N:3]([CH3:15])[CH:4]=[CH:5][C:6]=1[S:7]([NH2:10])(=[O:8])=[O:9]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 196938302-bromo-N-(1,1-dimethylethyl)-1-methyl-1H-pyrrole-3-sulfonamide

생성물 1

HCID 196938442-Bromo-1-methyl-1H-pyrrole-3-sulfonamide수율 21.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 7.11 g (24 mmol) of 2-bromo-N-(1,1-dimethylethyl)-1-methyl-1H-pyrrole-3-sulfonamide in 50 mL methylene chloride under a nitrogen atmosphere was added 50 mL of TFA. The reaction mixture was allowed to stir at room temperature overnight ca. 16 hours. The reaction mixture was concentrated in vacuo. Three portions of diethyl ether were added to the crude residue and was removed by evaporation to remove residual TFA, which yielded 1.23 g of the title compound as a light brown solid. 1H NMR (Acetone-d6, 200 MHz.) δ: 7.36(d,1H), 6.49(d,1H), 6.3(bs,2H) 3.68(s,3H).

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. additionThree portions of diethyl ether were added to the crude residue
  3. customwas removed by evaporation
  4. customto remove residual TFA, which

출처 및 근거

ORD 기록
ord-24fca5966e304194948bc21b192c7f7a
출처 데이터셋
uspto-grants-1995_12
특허 번호
US05472933

연결된 노트

불러오는 중…