HCID 19002930, 화합물 → HCID 19002888, 화합물
반응식
Cl[C:2]1[O:10][C:9]2[C:4](=[N:5][C:6]([CH3:11])=[CH:7][CH:8]=2)[C:3]=1[Cl:12].C([Li])(C)(C)C>C1COCC1>[Cl:12][C:3]1[C:4]2=[N:5][C:6]([CH3:11])=[CH:7][CH:8]=[C:9]2[O:10][CH:2]=1참가 물질
4
실험 절차
To a solution of 2,3-dichloro-5-methylfuro[3,2-b]pyridine (0.661 g, 3.27 mmol) (Example 12, Step 2) in 16 mL of THF was added a 1.7M solution of t-butyllithium (4.04 mL, 6.87 mmol). After 30 min the solution was quenched at -78° C. with methanol and a solution of NH4C1. The reaction was brought to room temperature and extracted with EtOAc. The organic solvents were evaporated and the title compound was purified by flash chromatography on silica with EtOAc:hexane 1:4 to yield 0.444 g (81%).
후처리
- customAfter 30 min the solution was quenched at -78° C. with methanol
- customwas brought to room temperature
- extractionextracted with EtOAc
- customThe organic solvents were evaporated
- customthe title compound was purified by flash chromatography on silica with EtOAc:hexane 1:4
- customto yield 0.444 g (81%)
출처 및 근거
- ORD 기록
- ord-06347123ff744e688129a25fe29d93b1
- 출처 데이터셋
- uspto-grants-1995_12
- 특허 번호
- US05472964
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