HCID 19002173, 화합물 → HCID 178438424, 화합물
반응식
C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[C:19]3[CH:24]=[CH:23][C:22]([CH2:25][N:26]4[N:30]5[N:31]=[C:32]([CH3:34])[N:33]=[C:29]5[C:28]([CH2:35][C:36]5[CH:41]=[CH:40][C:39]([C:42]6[CH:47]=[CH:46][CH:45]=[CH:44][C:43]=6[C:48]6[N:52](C(C7C=CC=CC=7)(C7C=CC=CC=7)C7C=CC=CC=7)[N:51]=[N:50][N:49]=6)=[CH:38][CH:37]=5)=[C:27]4[CH2:72][CH2:73][CH3:74])=[CH:21][CH:20]=3)=[N:11][N:10]=[N:9]2)C=CC=CC=1>C1(C)C=CC=CC=1>[NH:11]1[C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]2[CH:20]=[CH:21][C:22]([CH2:25][N:26]3[N:30]4[N:31]=[C:32]([CH3:34])[N:33]=[C:29]4[C:28]([CH2:35][C:36]4[CH:41]=[CH:40][C:39]([C:42]5[CH:47]=[CH:46][CH:45]=[CH:44][C:43]=5[C:48]5[NH:49][N:50]=[N:51][N:52]=5)=[CH:38][CH:37]=4)=[C:27]3[CH2:72][CH2:73][CH3:74])=[CH:23][CH:24]=2)=[N:8][N:9]=[N:10]1참가 물질
3
실험 절차
A 342 mg portion of 5,7-bis[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-2-methyl-6-propyl-5H-pyrazolo[1,5-b][1,2,4]triazole (compound 1a) was treated in the same manner as described in Example 12, the resulting residue was mixed with toluene and heated under reflux and then the solution was cooled spontaneously to collect the thus formed precipitate by filtration, thereby giving 182 mg of 5,7-bis[[2'-(tetrazol-5-yl)biphenyl-4-yl]methyl]-2-methyl- 6-propyl-5H-pyrazolo[1,5-b][1,2,4]triazole in the form of colorless amorphous solid.
후처리
- temperatureheated