Cidofovir → [(2R)-1-(4-amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-propan-2-yl]oxymethylphosphonic acid

HRID 2260332

반응식

HRID 2260332 반응식
C1O[C@H]1CO.C(NC1C=CNC(=O)N=1)(=O)C1C=CC=CC=1.[CH:22]1[C:28]([NH2:29])=[N:27][C:25](=[O:26])[N:24]([CH2:30][C@H:31]([O:34][CH2:35][P:36]([OH:39])([OH:38])=[O:37])[CH2:32][OH:33])[CH:23]=1>>[CH:22]1[C:28]([NH2:29])=[N:27][C:25](=[O:26])[N:24]([CH2:30][C@@H:31]([O:34][CH2:35][P:36]([OH:39])([OH:38])=[O:37])[CH2:32][OH:33])[CH:23]=1

참가 물질

4

반응물 3

HCID 60613CidofovirHCID 6973630(-)-GlycidolHCID 178522337HCID 178522337, 화합물

생성물 1

HCID 513605[(2R)-1-(4-amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-propan-2-yl]oxymethylphosphonic acid

실험 절차

The title compound (R)-HPMPC was prepared from (S)-glycidol (88% ee) and N4 -benzoylcytosine, following the method described for (S)-HPMPC.

출처 및 근거

ORD 기록
ord-446b43d0cd8444ea817f87830835fae1
출처 데이터셋
uspto-grants-1995_12
특허 번호
US05476938

연결된 노트

불러오는 중…