(4S,5R)-3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyl-1,3-oxazolidine-5-carboxylic acid → HCID 54422886, 화합물

HRID 2260389노트

반응식

HRID 2260389 반응식
C(OC(N1[C@@H](C2C=CC=CC=2)[C@H](C(O)=O)OC1(C)C)=O)(C)(C)C.[C:24]([O:28][C:29]([N:31]1[C@@H:35]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[C@H:34]([C:42]([O:44]CC)=[O:43])[O:33][C:32]1([CH2:49][CH3:50])[CH2:47][CH3:48])=[O:30])([CH3:27])([CH3:26])[CH3:25]>>[C:24]([O:28][C:29]([N:31]1[C@@H:35]([C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=2)[C@H:34]([C:42]([OH:44])=[O:43])[O:33][C:32]1([CH2:49][CH3:50])[CH2:47][CH3:48])=[O:30])([CH3:27])([CH3:26])[CH3:25]

참가 물질

3

반응물 2

HCID 10969286(4S,5R)-3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyl-1,3-oxazolidine-5-carboxylic acidHCID 54436966HCID 54436966, 화합물

생성물 1

HCID 54422886HCID 54422886, 화합물수율 79.8%

실험 절차

(4S,5R)-3-tert-Butoxycarbonyl-2,2-diethyl-4-phenyl-5-oxazolidinecarboxylic acid may be obtained under the conditions described in Example 6 for the preparation of (4S,5R)-3-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-5-oxazolidinecarboxylic acid. Thus, starting with 2.3 g of ethyl (4S,5R)-3-tert-butoxycarbonyl-2,2-diethyl-4-phenyl-5-oxazolidinecarboxylate, 1.7 g of (4S,5R)-3-tert-butoxycarbonyl-2,2-diethyl-4-phenyl-5-oxazolidinecarboxylic acid is obtained in the form of white crystals, melting point 185° C.

출처 및 근거

ORD 기록
ord-45d52ba0e02a4a159994600b5513d0eb
출처 데이터셋
uspto-grants-1995_12
특허 번호
US05476954

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