Hexane → HCID 131719232, 화합물

HRID 2260639

반응식

HRID 2260639 반응식
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH2:20][OH:21])[CH2:14][CH2:13]3)=[N:7][N:8]2[CH3:11])=[CH:4][CH:3]=1.CCCCCC.[N:28]1([C:38]([Cl:40])=[O:39])[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH2:31][CH2:30][CH2:29]1>>[ClH:40].[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH2:20][O:21][C:38]([N:28]4[C:37]5[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=5)[CH2:31][CH2:30][CH2:29]4)=[O:39])[CH2:14][CH2:13]3)=[N:7][N:8]2[CH3:11])=[CH:4][CH:3]=1

참가 물질

4

반응물 3

HCID 8058HexaneHCID 135910693,4-Dihydroquinoline-1(2H)-carbonyl chlorideHCID 189987994-(6-fluoro-1-methyl-1H-indazol-3-yl)-1-(3-hydroxypropyl)piperidine

생성물 1

HCID 131719232HCID 131719232, 화합물수율 9%

실험 절차

Starting from 4-(6-fluoro-1-methyl-I H-indazol-3-yl)-1-(3-hydroxypropyl)piperidine (370 mg; 1.2 mmol), 3M N-butyl lithium in hexane (0.7 ml; 2.1 mmol) and 1,2,3,4-tetrahydroquinolin-1-carbonyl chloride (300 mg; 1.5 mmol) using the procedure described in example 7 was prepared 50 mg (9%) of the title compound.

출처 및 근거

ORD 기록
ord-31343d9265cc4db2b44015268aeeb1b4
출처 데이터셋
uspto-grants-1995_12
특허 번호
US05478845

연결된 노트

불러오는 중…