Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Styrene Oxide → 1-(2-hydroxy-2-phenyl-ethyl)-4-(6-fluoro-1-methyl-1H-indazol-3-yl)-piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Styrene Oxide | HCID 7276 | — |
| 반응물 | 6-Fluoro-1-methyl-3-(piperidin-4-yl)-1H-indazole | HCID 14032608 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 1-(2-hydroxy-2-phenyl-ethyl)-4-(6-fluoro-1-methyl-1H-indazol-3-yl)-piperidine | HCID 18998823 | 33% |
반응 단계
A mixture of 4-(6-fluoro-1-methyl-1H-indazol-3-yl)piperidine (1 g; 4.3 mmol) and phenyloxirane (0.6 g; 5 mmol) in 10 ml acetonitrile was refluxed for 16 h. The cooled reaction mixture was concentrated in vacuo and purified by chromatography on silica gel 60 with ethyl acetate: methanol (9:1, v/v) as eluent. Concentration of the appropriate fractions gave 500 mg (33%) of 1-(2-hydroxy-2-phenyl-ethyl)-4-(6-fluoro-1-methyl-1H -indazol-3-yl)-piperidine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05478845 |
| 출처 데이터셋 | uspto-grants-1995_12 |
| ORD ID | ord-57e9edea1081492480bb53605c9388f9 |
| 출처 메모 | uspto-grants-1995_12 |