Trifluoroacetic acid → (3S,4R)-ethyl 4-(allyloxycarbonyl)piperidine-3-carboxylate
반응식
[CH2:1]([O:4][C:5]([C@@H:7]1[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][C@H:8]1[C:20]([O:22][CH2:23][CH3:24])=[O:21])=[O:6])[CH:2]=[CH2:3].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:1]([O:4][C:5]([C@@H:7]1[CH2:12][CH2:11][NH:10][CH2:9][C@H:8]1[C:20]([O:22][CH2:23][CH3:24])=[O:21])=[O:6])[CH:2]=[CH2:3]참가 물질
4
실험 절차
A solution of 259B (680 mg, 1.9 mmol) in CH2Cl2 (10 mL) was treated with TFA (1 mL) at room temperature. The reaction mixture was stirred for 16 hours, then concentrated. The residues was dissolved in EtOAc (20 mL) and washed with saturated aqueous NaHCO3 (2×20 mL), dried (Na2SO4), filtered and concentrated in vacuo to afford 170 mg of Compound 259C.
후처리
- concentrationconcentrated
- dissolutionThe residues was dissolved in EtOAc (20 mL)
- washwashed with saturated aqueous NaHCO3 (2×20 mL)
- dry with materialdried (Na2SO4)
- filtrationfiltered
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-e0cfce801b3d42f9a8a576287ef71981
- 출처 데이터셋
- uspto-grants-2010_12
- 특허 번호
- US07846931B2
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