1-Phenethylamine → Armodafinil

HRID 22612

반응식

HRID 22612 반응식
[CH:1]1[CH:2]=[CH:3][C:4]([CH:7]([S+:14]([O-:19])[CH2:15][C:16]([NH2:18])=[O:17])[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)=[CH:5][CH:6]=1.C1(C(C2C=CC=CC=2)S(CC(O)=O)=O)C=CC=CC=1.CC(N)C1C=CC=CC=1>C(O)C>[CH:11]1[CH:10]=[CH:9][C:8]([CH:7]([S@@:14]([CH2:15][C:16]([NH2:18])=[O:17])=[O:19])[C:4]2[CH:5]=[CH:6][CH:1]=[CH:2][CH:3]=2)=[CH:13][CH:12]=1

참가 물질

5

반응물 3

HCID 74081-PhenethylamineHCID 3085267Modafinil acidHCID 178514057HCID 178514057, 화합물

생성물 1

HCID 9690109Armodafinil

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

U.S. Pat. No. 4,927,855 describes the preparation of the levorotatory enantiomer of modafinil by chiral resolution of the 2-[(diphenylmethyl)sulfinyl]acetic acid with α-methylbenzyl amine. After recovery and amidation of the enantiomerically pure acid, (−) modafinil was obtained as white crystals by crystallization from ethanol.

출처 및 근거

ORD 기록
ord-873f2f7db5f04ea2a3c8c69096c5bc0a
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06849120B2

연결된 노트

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