Dichloromethane → 3-(3-p-Tolylsulfamoyl-phenyl)-acryloyl chloride

HRID 226127노트

반응식

HRID 226127 반응식
[C:1]1([CH3:22])[CH:6]=[CH:5][C:4]([NH:7][S:8]([C:11]2[CH:12]=[C:13]([CH:17]=[CH:18][C:19](O)=[O:20])[CH:14]=[CH:15][CH:16]=2)(=[O:10])=[O:9])=[CH:3][CH:2]=1.[Cl:23]CCl>CN(C)C=O>[C:1]1([CH3:22])[CH:6]=[CH:5][C:4]([NH:7][S:8]([C:11]2[CH:12]=[C:13]([CH:17]=[CH:18][C:19]([Cl:23])=[O:20])[CH:14]=[CH:15][CH:16]=2)(=[O:10])=[O:9])=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 6344DichloromethaneHCID 670195353-(3-p-Tolylsulfamoyl-phenyl)-acrylic acid

생성물 1

HCID 739893963-(3-p-Tolylsulfamoyl-phenyl)-acryloyl chloride수율 99.7%

시약·촉매·용매 1

HCID 6228Dimethylformamide촉매

반응 조건

온도
40 °C

실험 절차

To a suspension of 3-(3-p-tolylsulfamoyl-phenyl)-acrylic acid (5d) (0.75 g, 2.36 mmol) in dichloromethane (10.0 ml) oxalyl chloride (0.62 ml, 7.08 mmol) and one drop of dimethylformamide were added. The reaction mixture was stirred at 40° C. for one hour and concentrated under reduced pressure to give crude title compound (0.79 g).

후처리

  1. additionwere added
  2. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-ec7431507b994fe788d62ba58e7326dd
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07557140B2

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