Thionyl Chloride → 1-Benzyl-4-(chloromethyl)-1H-pyrazole hydrochloride
반응식
[CH2:1]([N:8]1[CH:12]=[C:11]([CH2:13]O)[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:17])=O>ClCCl>[ClH:17].[CH2:1]([N:8]1[CH:12]=[C:11]([CH2:13][Cl:17])[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1참가 물질
4
실험 절차
1.88 g of (1-benzyl-1H-pyrazol-4-yl)methanol was dissolved in 30 ml of dichloromethane, and 2.1 ml of thionyl chloride was added. The mixture was stirred at room temperature for 5 hours. The reaction mixture was concentrated under reduced pressure to obtain 2.39 g of 1-benzyl-4-(chloromethyl)-1H-pyrazole hydrochloride.
후처리
- concentrationThe reaction mixture was concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-4a99bdcd3ffa489d9110a75bc35c9670
- 출처 데이터셋
- uspto-grants-2010_12
- 특허 번호
- US07846956B2
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