Water → 1-(5-t-Butyl-isoxazol-3-yl)ethanol
반응식
[C:1]([C:5]1[O:9][N:8]=[C:7]([CH:10]=[O:11])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:12][Mg]Br.O>O1CCCC1>[C:1]([C:5]1[O:9][N:8]=[C:7]([CH:10]([OH:11])[CH3:12])[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]참가 물질
5
실험 절차
1.29 g of 5-t-butyl-isoxazole-3-carbaldehyde was dissolved in 10 ml of tetrahydrofuran, and 10 ml of a 0.93 M solution of methylmagnesium bromide in tetrahydrofuran was then added. The mixture was stirred for 1 hour under ice-cooling. After water was added, the reaction mixture was extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium sulfate, filtered and then concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 1.18 g of 1-(5-t-butyl-isoxazol-3-yl)ethanol.
후처리
- temperaturecooling
- extractionthe reaction mixture was extracted with ethyl acetate
- washThe organic layer was washed with water
- dry with materialdried over anhydrous magnesium sulfate
- filtrationfiltered
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-a1048bd2ad6648c3b12c89147efb694c
- 출처 데이터셋
- uspto-grants-2010_12
- 특허 번호
- US07846956B2
반응 노트
불러오는 중…