Water → 3-(1-Chloroethyl)-5-t-butylisoxazole
반응식
[C:1]([C:5]1[O:9][N:8]=[C:7]([CH:10](O)[CH3:11])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].C1(C)C=CC(S([Cl:22])(=O)=O)=CC=1.O>N1C=CC=CC=1>[Cl:22][CH:10]([C:7]1[CH:6]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[O:9][N:8]=1)[CH3:11]참가 물질
5
실험 절차
1.18 g of 1-(5-t-butyl-isoxazol-3-yl)ethanol was dissolved in 2 ml of pyridine, and 1.36 of 4-toluenesulfonyl chloride was then added under ice-cooling. The mixture was stirred for 5 hours under ice-cooling. After water was added, the reaction mixture was extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium sulfate, filtered and then concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 1.60 g of 3-(1-chloroethyl)-5-t-butylisoxazole.
후처리
- temperaturecooling
- temperaturecooling
- extractionthe reaction mixture was extracted with ethyl acetate
- washThe organic layer was washed with water
- dry with materialdried over anhydrous magnesium sulfate
- filtrationfiltered
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-ac395ad5524a47ecbf37e8d382f3a00e
- 출처 데이터셋
- uspto-grants-2010_12
- 특허 번호
- US07846956B2
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