2-tert-Butyl-4-methylphenol → 2-Bromo-4-methyl-6-tert-butylphenol
반응식
[C:1]([C:5]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:6]=1[OH:12])([CH3:4])([CH3:3])[CH3:2].[Br:13]Br>C(Cl)Cl>[C:1]([C:5]1[CH:10]=[C:9]([CH3:11])[CH:8]=[C:7]([Br:13])[C:6]=1[OH:12])([CH3:4])([CH3:3])[CH3:2]참가 물질
4
실험 절차
2-t-Butyl-4-methylphenol (10 g, 60.8 mmol) is dissolved in CH2Cl2 (300 mL). Bromine (3.1 mL, 60.8 mmol) is added dropwise to the solution. After 20 minutes, the crude mixture is washed with H2O, dried over MgSO4, filtered and rotovapped to give yellow oil: 12.6 g, 85%. 1H NMR (CDCl3) δ: 1.402 (s, 9H, t-Bu), 2.267 (s, 3H, CH3), 5.640 (s, 1H, OH), 7.017 (s, 1H, Ar), 7.167 (s, 1H, Ar).
후처리
- washthe crude mixture is washed with H2O
- dry with materialdried over MgSO4
- filtrationfiltered
- customto give yellow oil
출처 및 근거
- ORD 기록
- ord-797882cd13494660a7d156002f0b2b14
- 출처 데이터셋
- uspto-grants-2010_12
- 특허 번호
- US07847099B2
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