(2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenylphosphinomethyl-pyrrolidine → Mitiglinide
반응식
CC(OC(N1[C@H](CP(C2C=CC=CC=2)C2C=CC=CC=2)C[C@H](P(C2C=CC=CC=2)C2C=CC=CC=2)C1)=O)(C)C.[CH:40](=[C:47]([CH2:51][C:52]([N:54]1[CH2:62][C@H:61]2[C@H:56]([CH2:57][CH2:58][CH2:59][CH2:60]2)[CH2:55]1)=[O:53])[C:48]([OH:50])=[O:49])[C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1>>[CH:44]1[CH:43]=[CH:42][C:41]([CH2:40][C@H:47]([C:48]([OH:50])=[O:49])[CH2:51][C:52]([N:54]2[CH2:55][C@H:56]3[C@H:61]([CH2:60][CH2:59][CH2:58][CH2:57]3)[CH2:62]2)=[O:53])=[CH:46][CH:45]=1참가 물질
3
실험 절차
The preparation was carried out in the same manner as in Example 1, except that 2.92 mg of BPPM was used instead of 3.02 mg of PCPPM of Example 1. After the reaction, the residual ratio of 2-benzylidene-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid was 10.85%, and the optical purity of mitiglinide thus obtained was 96.1% e.e.
후처리
- customAfter the reaction