4-Methyl-2-oxovaleric acid → Methyl 4-methyl-2-oxopentanoate

HRID 2261726노트

반응식

HRID 2261726 반응식
[CH3:1][CH:2]([CH3:9])[CH2:3][C:4](=[O:8])[C:5]([OH:7])=[O:6].Cl[Si](C)(C)[CH3:12]>CO.COC(OC)(C)C>[CH3:12][O:6][C:5](=[O:7])[C:4](=[O:8])[CH2:3][CH:2]([CH3:9])[CH3:1]

참가 물질

5

반응물 2

HCID 704-Methyl-2-oxovaleric acidHCID 6397Chlorotrimethylsilane

생성물 1

HCID 546077Methyl 4-methyl-2-oxopentanoate

시약·촉매·용매 2

HCID 887Methanol용매HCID 64952,2-Dimethoxypropane용매

실험 절차

To a solution of 4-methyl-2-oxo-pentanoic acid (3.4 g, 26 mmol) in methanol (12 mL) and 2,2-dimethoxypropane (48 mL) is added chlorotrimethylsilane (0.38 mL). The reaction mixture is stirred at ambient temperature overnight. The reaction mixture is concentrated under reduced pressure to give the title compound as an oil, (3.8 g, quant.). 1H NMR (400 MHz, CDCl3): δ 3.86 (s, 3H), 2.72 (d, 2H), 2.16 (m, 1H), 0.96 (d, 6H).

후처리

  1. concentrationThe reaction mixture is concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-9c94aee87db64cf4a8fffb905caea73e
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07846960B2

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