Methanol → 3-{3-[(Benzo[1,3]dioxol-5-ylmethyl)sulfamoyl]-phenyl}-acrylic acid

HRID 226191노트

반응식

HRID 226191 반응식
C[O:2][C:3](=[O:26])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([S:12](=[O:25])(=[O:24])[NH:13][CH2:14][C:15]2[CH:23]=[CH:22][C:18]3[O:19][CH2:20][O:21][C:17]=3[CH:16]=2)[CH:7]=1.CO>>[O:19]1[C:18]2[CH:22]=[CH:23][C:15]([CH2:14][NH:13][S:12]([C:8]3[CH:7]=[C:6]([CH:5]=[CH:4][C:3]([OH:26])=[O:2])[CH:11]=[CH:10][CH:9]=3)(=[O:25])=[O:24])=[CH:16][C:17]=2[O:21][CH2:20]1

참가 물질

3

반응물 2

HCID 887MethanolHCID 670196013-{3-[(Benzo[1,3]dioxol-5-ylmethyl)-sulfamoyl]-phenyl}acrylic Acid Methyl Ester

생성물 1

HCID 670195213-{3-[(Benzo[1,3]dioxol-5-ylmethyl)sulfamoyl]-phenyl}-acrylic acid

실험 절차

To a suspension of 3-{3-[(benzo[1,3]-dioxol-5-ylmethyl)-sulfamoyl]-phenyl}-acrylic acid methyl ester (0.47 g, 1.25 mmol) in methanol (6 ml) 1N NaOH solution (3.75 ml, 3.75 mmol) was added and the resultant mixture was stirred at ambient temperature overnight. The reaction mixture was partitioned between ethyl acetate and water. The aqueous layer was acidified with 2N HCl solution and stirred for 30 min. The precipitated solid was filtered, washed with water and dried in desiccator over P2O5. The title compound was obtained as a white solid (0.39 g, 87%).

후처리

  1. additionwas added
  2. customThe reaction mixture was partitioned between ethyl acetate and water
  3. filtrationThe precipitated solid was filtered
  4. washwashed with water
  5. dry with materialdried in desiccator over P2O5

출처 및 근거

ORD 기록
ord-6dccf3be1ebc4cbc8e7a3a05957cce40
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07557140B2

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