Methanol → Methyl 2-[(4-amino-3-nitrophenyl)carbonyl]benzoate

HRID 2261925노트

반응식

HRID 2261925 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=2[C:12]([OH:14])=[O:13])=[O:9])=[CH:4][C:3]=1[N+:19]([O-:21])=[O:20].S(=O)(=O)(O)O.[CH3:27]O>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=2[C:12]([O:14][CH3:27])=[O:13])=[O:9])=[CH:4][C:3]=1[N+:19]([O-:21])=[O:20]

참가 물질

4

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 27975222-(4-Amino-3-nitrobenzoyl)benzoic acid

생성물 1

HCID 14994663Methyl 2-[(4-amino-3-nitrophenyl)carbonyl]benzoate

실험 절차

A solution of 2-[(4-amino-3-nitrophenyl)carbonyl]benzoic acid (4.60 g, 16.00 mmol) in methanol (300 mL) in the presence of catalytic amount of cc. sulfuric acid was heated to reflux for 18 h. The solution was cooled to room temperature and the solvent was evaporated. The yellow precipitate formed was collected by filtration, washed with water and dried in vacuo to provide methyl 2-[(4-amino-3-nitrophenyl)carbonyl]benzoate (4.8 g, quantitative). MS (EI) for C15H12N2O5: 301 (MH+).

후처리

  1. temperatureto reflux for 18 h
  2. customthe solvent was evaporated
  3. customThe yellow precipitate formed
  4. filtrationwas collected by filtration
  5. washwashed with water
  6. customdried in vacuo

출처 및 근거

ORD 기록
ord-7b5ba5cfa6504cbaab1410ddcbd82788
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07846959B2

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