Dicyclohexylcarbodiimide → 2-Tert-butoxycarbonylamino-succinic acid 1-benzyl ester 4-(2,5-dioxo-pyrrolidin-1-yl) ester

참여 물질

역할	이름	HCID	투입량
반응물	Dicyclohexylcarbodiimide	HCID 10868	—
반응물	N-Hydroxysuccinimide	HCID 80170	—
반응물	(3S)-4-(benzyloxy)-3-(((tert-butoxy)carbonyl)amino)-4-oxobutanoic acid	HCID 7017887	—
용매	Ethyl Acetate	HCID 8857	—
생성물	2-Tert-butoxycarbonylamino-succinic acid 1-benzyl ester 4-(2,5-dioxo-pyrrolidin-1-yl) ester	HCID 21844024	—

반응 조건

온도	0 °C

반응 단계

A solution of BOC-Asp-OBzl (1.49 g, 4.61 mmol) and N-Hydroxy succinimide (584 mg, 5.07 mmol) in EtOAc (20 ml) was cooled to 0° C. 1,3-Dicyclohexylcarbodiimide (1.05 g, 5.07 mmol) was added portionwise. White precipitate began forming. The resulting mixture was stirred at 0° C. for 10 min. and then allowed to warm to rt. After stirring for 6 h. at rt the mixture was filtered and concentrated in vacuo to give 2-tert-butoxycarbonylamino-succinic acid 1-benzyl ester 4-(2,5-dioxo-pyrrolidin-1-yl) ester as a clear, colorless oil which was used without further purification.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07557137B2
출처 데이터셋	uspto-grants-2009_07
ORD ID	ord-e3db878e444d437794e28b882efd8c39
출처 메모	uspto-grants-2009_07