Potassium Carbonate → 3,4,5-Trimethylpyridin-2-amine
반응식
[NH2:1][C:2]1[C:7]([CH3:8])=[C:6]([CH3:9])[C:5](Br)=[CH:4][N:3]=1.[CH3:11]B1OB(C)OB(C)O1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[NH2:1][C:2]1[C:7]([CH3:8])=[C:6]([CH3:9])[C:5]([CH3:11])=[CH:4][N:3]=1참가 물질
5
반응 조건
- 온도
- 115 °C
실험 절차
23.0 g (0.11 mol) of 2-amino-5-bromo-3,4-dimethylpyridine was mixed with 14.1 g (0.11 mol) of trimethylboroxin (TMB), 12.9 g (0.011 mol) of Pd(Ph3)4, 46.0 g (0.33 mol) of K2CO3 and 220 mL of DMF. The reaction mixture was heated under nitrogen at 115° C. for 18 hours. The reaction mixture was purified by silica gel column. The desired product was confirmed by MS.
후처리
- customThe reaction mixture was purified by silica gel column
출처 및 근거
- ORD 기록
- ord-1095533390e843719ebd5cdf846d741a
- 출처 데이터셋
- uspto-grants-2010_12
- 특허 번호
- US07851072B2
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