Sodium Bicarbonate → (2Z)-3-Amino-2-cyano-4-ethyl-2-hexene
반응식
[NH2:1]/[C:2](/[CH:9]([CH2:12][CH3:13])[CH2:10][CH3:11])=[C:3](/[C:7]#[N:8])\[C:4](Cl)=O.C([O-])(O)=O.[Na+]>C(#N)C.O>[NH2:1]/[C:2](/[CH:9]([CH2:10][CH3:11])[CH2:12][CH3:13])=[C:3](\[C:7]#[N:8])/[CH3:4]참가 물질
5
반응 조건
- 온도
- 25 °C
실험 절차
3 g (15 mmol) of (2Z)-3-amino-2-cyano-4-ethyl-2-hexenoyl chloride dissolved in acetonitrile were added dropwise to a solution of 2.6 g (30 mmol) NaHCO3 in water. The solution was stirred at 25° C. for 30 min, then concentrated to dryness and the residue was taken up in methanol. The precipitate was seperated and the filtrate concencentrated to dryness again. The residue was dissolved in water and saturated KHSO4-solution was added. Filtration of the precipitate gave 2 g of the title compound (73% of theory) as a colorless solid (m. p. 150° C.)
후처리
- concentrationconcentrated to dryness
- customThe precipitate was seperated
- dissolutionThe residue was dissolved in water
- additionsaturated KHSO4-solution was added
- filtrationFiltration of the precipitate
출처 및 근거
- ORD 기록
- ord-12016601758e4ca2949e51d73b61092e
- 출처 데이터셋
- uspto-grants-2010_12
- 특허 번호
- US07851411B2
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